
endo stages
American Society of Reproductive Medicine (ASRM) classification
There is no consensus on the classification of endometriosis. The most used system is that of the American Society of Reproductive Medicine (ASRM). This system was designed with a focus on the impact on fertility and not necessarily the impact on patients' quality of life. Endometriosis is classified into four stages depending on the location, extent and depth of endometriosis implants and adhesions.
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Stage 1, minimal endometriosis (5 points or less), also called superficial peritoneal endometriosis
The lesions are small and superficial. Scar tissue is minimal or non-existent.
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Stage 2, mild endometriosis (between 5 and 15 points), endometriomas
More injuries and and they tend to be located deeper inside the tissue. There may be some scar tissue, but there is usually no inflammation yet.
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Stage 3, moderate endometriosis (between 16 and 40 points), also known as deep infiltrative endometriosis
Presence of multiple and deep endometriosis implants. There may be endometriomas or chocolate cysts on the ovaries. These cysts are formed when implants surround the ovaries and when they bleed, they leave old brown blood that collects in a capsule that can grow and be very painful when they leak. These bands of scar tissue can fuse the organs together.
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Stage 4, severe endometriosis (more than 40 points), or abdominal wall endometriosis
Infertility at this stage is very likely due to distortion of the morphology of the abdominal wall. It is characterised by numerous and deep implants. The implants can be in the fallopian tubes and intestines. Endometriosis adhesions can be thick and deep and cause severe pain. There may be numerous and/or large cysts on the ovaries, and between the uterus and rectum.
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Enzian survey
Another classification, more for the purposes of evaluating deep endometriosis, is the Enzian. The questionnaire goes far beyond the typical areas of endometriosis: ovaries, tubes and peritoneum, the membrane that lines the abdominopelvic cavity and covers its organs. Includes scoring for injuries in the following locations:
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Vagina
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Rectovaginal space, area between the vagina and rectum, the final part of the large intestine
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Retrocervical area, i.e. behind the cervix
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Pelvic wall
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Cardinal ligaments that connect the uterus to the pelvis
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Sacral uterine ligaments that connect the uterus to the sacrum bone)
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Pelvic sidewall
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Adenomyosis
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Bladder
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Intestines
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Ureters
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Other locations: diaphragm, lungs, nerves… Endometriosis can appear anywhere.
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Resources and sources
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ASRM questionnaire, available at https://pmc.ncbi.nlm.nih.gov/articles/PMC7787892/figure/f1-yujm-2020-00444/, retrieved on 21 October 2024
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Eziam questionnaire, available at http://www.endometriose-sef.de/dateien/ENZIAN_2013_web.pdf, retrieved on 21 October 2024
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Surrey, Eric Dr.. (2023, 1 de Março). Endometriosis 101: The 4 Stages & Treatment Options. CCRM Fertility. https://www.ccrmivf.com/blog/four-stages-of-endometriosis/#:~:text=Very%20extensive%20stage%204%20endometriosis,bowel%20surgeon%20and%2For%20urologist, retrieved on 21 October 2024
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MulherEndo association, https://mulherendo.pt, retrieved on 21 October 2024
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Ginemed fertility clinic, https://ginemed.pt/reproducao-assistida/unidade-de-endometriose/, retrieved on 21 October 2024